
Effect of polydextrose on subjective feelings of appetite during the satiation and satiety periods: a systematic review and meta-analysis. Ibarra A, Astbury N, Olli K, Alhoniemi E, Tiihonen K. Learning to implement a lifestyle that includes a balanced eating plan, physical activity, stress reduction, and plenty of sleep is a healthier approach than using unproven, expensive, and untested supplements that may do more harm than good.

There has been at least one report of serious liver damage attributed to garcinia cambogia supplementation.

Garcinia Cambogia: Reported adverse events include headache, nausea, and upper GI symptoms.Possible side effects may include headaches and urinary tract infections. Green Coffee Bean Extract: Amounts used in studies (up to 200mg/day) have been mostly well-tolerated.Chromium may also interact with certain medications including antacids, corticosteroids, insulin, nonsteroidal anti-inflammatory drugs, and others. At higher doses, reported adverse side effects include headache, diarrhea, constipation, vertigo, nausea, vomiting, and hives.

Chromium: The NIH reports that there are no safety concerns for recommended doses ranging from 20–45 mcg/day for adults.However, polydextrose is likely a FODMAP, so it may not be tolerated by people with irritable bowel syndrome. One study funded by a polydextrose maker DuPont indicated that 4–12 grams can be used without adverse side effects such as abdominal pain, bloating, or diarrhea. Polydextrose: Studies investigating the possible side effects of polydextrose are limited.
